When Patrick Dempsey auditioned for the role of Derek, he was afraid that he was not going to get the part. Show creator Shonda Rhimes' first reaction was: "The very first time I met him, I was absolutely sure that he was my guy. Reading the lines of Derek Shepherd, Patrick had a vulnerable charm that I just fell for. And he had amazing chemistry with Ellen Pompeo.
"I want to marry you. I want to have kids with you. I want to build us a house. I want to settle down and grow old with you. I want to die when I'm 110 years old in your arms. I don't want 48 uninterrupted hours. I want a lifetime." - The perfect man, Dr. Derek Sheppard <3